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What is the optimal sampling time and time to steady state for plasma digoxin concentration in dogs with and without experimental mitral regurgitation?
What is the optimal sampling time and time to steady state for plasma digoxin concentration in dogs with and without experimental mitral regurgitation?
In dogs with and without mitral regurgitation, steady-state plasma digoxin concentrations are achieved in 3-5 days, earlier than previously reported, with optimal sampling at 10-18 hours post-dose.
Refines digoxin monitoring windows in experimental canine MR models; leaves open clinical translation pending prospective veterinary trials.
Fifteen and eight mature beagles, without (normal group) and with experimental mitral regurgitation (MR group), respectively, were given 0.02 mg/kg/day digoxin powder for 10 days orally. The optimum time for sample collection after administration of digoxin was observed to be 8-18 hr and 10-22 hr in the normal and MR groups, respectively. In both groups, a stable concentration was reached after 3-5 days of treatment. No differences in plasma level were observed between sexes. The optimum concentration of digoxin was attained at an earlier stage than has been previously reported for both dogs and humans.
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Nagashima et al. (2001) studied this question.
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