Key result
Neoadjuvant chemotherapy followed by Kausch-Whipple pancreaticoduodenectomy resulted in the patient remaining disease-free 18 months following resection for duodenal Ewing's sarcoma.
Case Report (n=1)
This case demonstrates that rare Ewing's sarcoma of the duodenum can be successfully managed with neoadjuvant chemotherapy and surgical resection.
A man in his 40s with no medical history presented with right-sided abdominal and chest pain. A CT scan of the abdomen demonstrated a 7.7 cm heterogeneous mass arising from the second part of the duodenum. Oesophagogastroduodenoscopy confirmed a malignant-appearing duodenal lesion, with biopsy showing features consistent with small cell carcinoma. The patient underwent three cycles of neoadjuvant chemotherapy, followed by elective Kausch-Whipple pancreaticoduodenectomy. A combination of immunohistochemistry and molecular studies confirmed the diagnosis of a rare Ewing's sarcoma tumour originating from the duodenum with invasion into the duodenal lumen. The patient recovered well from surgery and remains disease-free 18 months following resection.
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Saiyed et al. (2023) conducted a case report in Ewing's sarcoma of the duodenum (n=1). Neoadjuvant chemotherapy and Kausch-Whipple pancreaticoduodenectomy was evaluated on Disease-free survival. Neoadjuvant chemotherapy followed by Kausch-Whipple pancreaticoduodenectomy resulted in the patient remaining disease-free 18 months following resection for duodenal Ewing's sarcoma.
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