Key result
The Master@Heart study is a prospective cohort trial designed to assess the incidence of mixed coronary plaques in male lifelong and late-onset endurance athletes compared to healthy non-athletes.
Why the study?
The health benefits of strenuous, prolonged endurance exercise have been challenged, as higher doses have been linked to greater coronary plaque burden, atrial fibrillation, and myocardial fibrosis.
Does lifelong or late-onset endurance training increase the incidence of mixed coronary plaques compared to a non-athletic lifestyle in men aged 45-70?
Comparison
Lifelong vs late-onset endurance athletes vs healthy non-athletes
Design
Multicentre prospective cohort study
Follow-up
1 year
Authors
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High-volume endurance exercise may warrant caution for AF and plaque risks; leaves open causality and safe thresholds.
Cohort (n=600)
Yes
Does lifelong or late-onset endurance training increase the incidence of mixed coronary plaques compared to a non-athletic lifestyle in men aged 45-70?
The Master@Heart study is designed to assess whether high doses of endurance exercise are associated with greater coronary atherosclerotic plaque burden, atrial fibrillation, and myocardial fibrosis.
Bosscher et al. (2021) conducted a cohort in Cardiovascular pathology (n=600). Lifelong and late-onset endurance training vs. Healthy non-athletes was evaluated on Incidence of mixed coronary plaques. The Master@Heart study is a prospective cohort trial designed to assess the incidence of mixed coronary plaques in male lifelong and late-onset endurance athletes compared to healthy non-athletes.
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