June 1, 1999Journal of Clinical Oncology
EWS-FLI1 and EWS-ERG Gene Fusions Are Associated With Similar Clinical Phenotypes in Ewing's Sarcoma
Key result
In 136 patients with Ewing's sarcoma, EWS-ERG gene fusions were associated with similar clinical phenotypes, event-free survival, and overall survival compared to EWS-FLI1 fusions.
Why the study?
Are EWS-FLI1 and EWS-ERG gene fusions associated with different clinical phenotypes in Ewing's sarcoma?
Population
136 cases of Ewing's sarcoma (30 with EWS-ERG gene fusion and 106 with EWS-FLI1 fusion)
Comparison
EWS-ERG gene fusion vs EWS-FLI1 gene fusion
Design
Cohort
Authors
Discussion
Loading...
Member takes
Implication
EWS-ERG fusions support equivalent prognosis to EWS-FLI1 in Ewing sarcoma; leaves open whether fusion subtyping refines risk stratification.
Study Design
Type
Cohort (n=136)
Structured PICO
Are EWS-FLI1 and EWS-ERG gene fusions associated with different clinical phenotypes in Ewing's sarcoma?
P
Population
136 patients with Ewing's sarcoma harboring either EWS-ERG or EWS-FLI1 gene fusions.
E
Exposure
EWS-ERG gene fusion
C
Comparator
EWS-FLI1 gene fusion
O
Outcome
Clinical differences including age of diagnosis, sex, metastasis at diagnosis, primary site, event-free survival, and overall survivalhard clinical
Differences in the C-terminal partner in Ewing's sarcoma family gene fusions (EWS-FLI1 vs EWS-ERG) are not associated with significant phenotypic or survival differences.
Cite This Study
Ginsberg et al. (1999) conducted a cohort in Ewing's sarcoma (n=136). EWS-ERG gene fusion vs. EWS-FLI1 gene fusion was evaluated on Clinical phenotypes including event-free survival and overall survival. In 136 patients with Ewing's sarcoma, EWS-ERG gene fusions were associated with similar clinical phenotypes, event-free survival, and overall survival compared to EWS-FLI1 fusions.