Why the study?
Does [Sar1,Thr8]angiotensin II reduce blood pressure in spontaneously hypertensive rats?
Population
Young and mature spontaneously hypertensive rats (SHR) under inactin anesthesia
Design
Preclinical
Authors
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Supports RAS role in genetic hypertension models; leaves open translation to human disease.
Does [Sar1,Thr8]angiotensin II reduce blood pressure in spontaneously hypertensive rats?
The study demonstrates that the renin-angiotensin system is involved in genetic hypertension in spontaneously hypertensive rats.
Muñoz-Ramírez et al. (1978) studied this question.
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