The aim is to review and discuss the concept of cryotherapy, its physiology, and different clinical implications in endodontics. Background: Cryotherapy alludes to diminishing the tissue temperature for therapeutic purposes. In the field of endodontics, it has started evolving due to its therapeutic properties and its effect on nickel-titanium endodontic instruments in terms of yielding mechanical properties. By using specific keywords, an electronic search of scientific papers was carried out on the entire PubMed database. The last access was august 2020, using combinations of the pre-defined keywords. Review results: The electronic search yielded 253 papers from the PubMed database; in light of inclusion and exclusion measures which were explicitly foreordained, 13 papers were distinguished as appropriate to the inclusion criteria. Then, a detailed study of all the references of these articles was done manually and electronically. At that point, 25 additional articles were chosen through hand search, the full content of the apparent multitude of articles recovered, and the review was finished. By pooling the separated information from chosen papers, the reviewed information was synthesized. Conclusion: Lately, by demonstrating great promising outcomes with the utilization of cryotherapy, it has demonstrated to have a decent possibility for its utilization as a therapeutic aid in endodontics. Clinical significance: Cryotherapy is a cost-effective treatment that can be advantageous in numerous clinical circumstances to provide painless and safer endodontic treatment.
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Agarwal et al. (2021) studied this question.
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