Why the study?
Does platelet-activating factor induce vasoconstriction in the hamster cheek pouch microcirculation?
Population
Hamster cheek pouch microcirculation model
Comparison
Platelet-activating factor applied topically at… vs Baseline/control vessel diameter
Design
Preclinical
Authors
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Does not warrant clinical changes in vascular management; extends mechanistic evidence on PAF-thromboxane pathways in microcirculation.
Does platelet-activating factor induce vasoconstriction in the hamster cheek pouch microcirculation?
Platelet-activating factor induces dose-dependent vasoconstriction in the microcirculation that is mediated by thromboxane A2 and PAF receptors.
Dillon et al. (1988) studied this question.
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