This study demonstrates that alpha-actinin is degraded rather than just released during post-mortem autolysis of myofibrils.
No immediate clinical implications; hypothesis-generating for Ca2+-dependent proteolysis in myofibrillar turnover.
The noted loss of alpha-actinin from the Z-line of myofibrils during post-mortem autolysis, probably following the action of calcium-activated protease, has previously been attributed to its release without degradation. This report shows that in isolated myofibrils alpha-actinin is proteolysed in a Ca2+-sensitive manner presumably via the action of calcium-activated protease.
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Kulesza-Lipka et al. (1985) studied this question.
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