What does this research mean for the field?

Alpha-actinin is a structural component of Z-filaments in skeletal muscle Z-disks, while the surrounding amorphous matrix is composed of Mr 75,000 and 55,000 proteins. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1989The Journal of Biochemistry

α-Actinin Is a Component of the Z-Filament, a Structural Backbone of Skeletal Muscle Z-Disks1

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Population

Glycerinated fiber bundles from psoas muscles of rabbit and breast muscles of chicken

Design

Preclinical

Follow-up

14 days

Authors

KTKoui TakahashiHokkaido University AHAkihito HattoriTokyo Institute of Technology

Discussion

Member takes

Implication

Establishes alpha-actinin as core Z-disk scaffold in skeletal muscle; extends ultrastructural models but leaves clinical translation open.

Structured PICO

Population

Glycerinated fiber bundles from psoas muscles of rabbit and breast muscles of chicken

Intervention

Treatment with a solution containing 0.1 mM Ca2+ for up to 14 days

Outcome

Structural changes in Z-disks and protein composition (alpha-actinin, Mr 75,000 and 55,000 proteins)surrogate

Alpha-actinin is identified as a structural component of Z-filaments in skeletal muscle Z-disks, while Mr 75,000 and 55,000 proteins comprise the amorphous matrix.

Cite This Study

Takahashi et al. (1989) studied this question.

synapsesocial.com/papers/6a1c85c72cc291e7bf2fe7c8 https://doi.org/10.1093/oxfordjournals.jbchem.a122701

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Implication

Establishes alpha-actinin as core Z-disk scaffold in skeletal muscle; extends ultrastructural models but leaves clinical translation open.

α-Actinin Is a Component of the Z-Filament, a Structural Backbone of Skeletal Muscle Z-Disks1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

α-Actinin Is a Component of the Z-Filament, a Structural Backbone of Skeletal Muscle Z-Disks1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider