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March 1, 1991Cell RegulationOpen Access

A second messenger RNA species of transforming growth factor beta 1 in infarcted rat heart.

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Population

Rat heart after experimental myocardial infarction caused by ligation of the left coronary artery

Comparison

Experimental myocardial infarction vs Normal heart tissue

Design

Preclinical

Authors

SQSu Wen QianMerck & Co., Inc., Rahway, NJ, USA (United States)PKPaturu KondaiahLaboratory of Molecular GeneticsWCWard CasscellsThe University of Texas Health Science Center at Houston

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Overview

Hypothesis-generating for alternative TGF-β1 regulation in post-MI remodeling; leaves open functional relevance in humans.

Structured PICO

P
Population
Rat heart after experimental myocardial infarction caused by ligation of the left coronary artery
I
Intervention
Experimental myocardial infarction (ligation of the left coronary artery)
C
Comparator
Normal heart tissue
O
Outcome
Detection and structural characterization of TGF-beta 1 mRNA transcriptssurrogate

The discovery of a novel 1.9-kb TGF-beta 1 mRNA transcript in infarcted rat hearts suggests different transcriptional and translational regulatory mechanisms of TGF-beta 1 in response to myocardial injury.

Cite This Study

Qian et al. (1991) studied this question.

synapsesocial.com/papers/6a91600eb68aa5977865e7d7https://doi.org/10.1091/mbc.2.3.241
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transforming Growth Factor Beta-1 in Acute Myocardial Infarction in Rats1988 · 232 citations
  2. 2Mediation of Cardioprotection by Transforming Growth Factor-β1990 · 299 citations
  3. 3New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.1981 · 920 citations
  4. 4Genomic sequencing.1984 · 8,222 citations
  5. 5cDNA cloning of porcine transforming growth factor-beta 1 mRNAs. Evidence for alternate splicing and polyadenylation.1988 · 94 citations