Key result
Cross-titration of antipsychotics while on lithium resulted in concomitant neuroleptic malignant syndrome and nephrogenic diabetes insipidus in 1 patient, causing hypovolemia and acute kidney injury.
Why the study?
An increased trend in psychiatric polypharmacy has heightened awareness of drug-drug interactions and adverse drug reactions.
Design
Case study
Authors
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Case of rare adverse events during antipsychotic cross-titration on lithium warrants vigilance in polypharmacy; leaves open prospective safety studies.
Case Report (n=1)
Psychiatric polypharmacy can obscure the presentation of adverse drug reactions such as concomitant neuroleptic malignant syndrome and diabetes insipidus.
Zaki et al. (2022) conducted a case report in Neuroleptic malignant syndrome and nephrogenic diabetes insipidus (n=1). Cross-titration of antipsychotics while on lithium was evaluated on Adverse drug reaction (NMS and diabetes insipidus). Cross-titration of antipsychotics while on lithium resulted in concomitant neuroleptic malignant syndrome and nephrogenic diabetes insipidus in 1 patient, causing hypovolemia and acute kidney injury.
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