Key result
No evidence was found for a circadian rhythm of plasma or urinary angiotensinogen in healthy volunteers or patients with chronic kidney disease.
Why the study?
Does plasma and urinary angiotensinogen exhibit a circadian rhythm in healthy volunteers and patients with chronic kidney disease?
Observational
Does plasma and urinary angiotensinogen exhibit a circadian rhythm in healthy volunteers and patients with chronic kidney disease?
Plasma and urinary angiotensinogen do not appear to exhibit a circadian rhythm, which may simplify its potential use as a biomarker for intrarenal renin-angiotensin system activity.
Answers are grounded in this paper and cite their sources.
May simplify angiotensinogen sampling timing; leaves open its validation as intrarenal RAS biomarker in prospective studies.
The urinary angiotensinogen (AGT) excretion rate could be a novel biomarker for the intrarenal activity of the renin-angiotensin system. Little is known about the circadian rhythm of AGT levels in plasma or urine. In this short article, making use of data in plasma and urine of healthy volunteers and patients with chronic kidney diseases, we first report that we were unable to find evidence for a circadian rhythm of AGT under any condition. Next we critically discuss to what degree elevated urinary AGT levels might be considered an independent biomarker that is not simply the non-specific consequence of proteinuria.
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Nishijima et al. (2014) conducted an observational in Chronic kidney disease. Circadian rhythm was evaluated on Circadian rhythm of angiotensinogen in plasma and urine. No evidence was found for a circadian rhythm of plasma or urinary angiotensinogen in healthy volunteers or patients with chronic kidney disease.
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