Key result
A fixed-dose combination of perindopril and indapamide resulted in a better efficacy and tolerability score (13.1) compared to sequential monotherapy (-7.2) and stepped-care (-17.5) strategies.
Why the study?
Does a fixed-dose combination strategy improve combined efficacy and tolerability scores compared to sequential monotherapy or stepped-care in patients with hypertension?
RCT (n=329)
Double-blind
random allocation
Does a fixed-dose combination strategy improve combined efficacy and tolerability scores compared to sequential monotherapy or stepped-care in patients with hypertension?
Absolute Event Rate: 13.1% vs -7.2%
A fixed-dose combination of perindopril/indapamide yielded better combined efficacy and tolerability scores than sequential monotherapy or stepped-care strategies in hypertension management.
No takes yet. Share an insight, caveat, or question.
Supports initial fixed-dose perindopril/indapamide in hypertension; extends RCT evidence favoring combinations over sequential or stepped-care strategies.
Bernard Waeber (2008) conducted an RCT in Hypertension (n=329). Fixed-dose combination strategy (perindopril/indapamide) vs. Sequential monotherapy (atenolol/losartan/amlodipine) or stepped-care strategy (valsartan/hydrochlorothiazide) was evaluated on Total score integrating the evolution of efficacy and tolerability over time. A fixed-dose combination of perindopril and indapamide resulted in a better efficacy and tolerability score (13.1) compared to sequential monotherapy (-7.2) and stepped-care (-17.5) strategies.
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