Key result
Patients with pulmonary embolism had a significantly higher 3-month incidence of major bleeding, recurrent PE, fatal PE, and overall death compared to those with DVT alone.
Why the study?
Do clinical characteristics and 3-month outcomes differ among patients presenting with acute DVT, PE, or both?
Population
13,919 patients, comprising 7,664 with acute deep vein thrombosis, 3,968 with pulmonary embolism, and 2,287…
Design
Cohort
Follow-up
3 months
Authors
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Supports closer PE surveillance than isolated DVT; leaves open whether presentation site should guide therapy intensity.
Cohort (n=13,919)
Do clinical characteristics and 3-month outcomes differ among patients presenting with acute DVT, PE, or both?
Patients presenting with PE or combined DVT/PE have worse 3-month clinical outcomes compared to those with DVT alone, suggesting they represent different clinical risk profiles despite being part of the venous thromboembolism spectrum.
Monreal et al. (2006) conducted a cohort in Acute deep vein thrombosis and/or pulmonary embolism (n=13,919). Pulmonary embolism (with or without DVT) vs. Deep vein thrombosis only was evaluated on 3-month clinical outcome including major bleeding, recurrent PE, fatal PE, overall death, and recurrent DVT. Patients with pulmonary embolism had a significantly higher 3-month incidence of major bleeding, recurrent PE, fatal PE, and overall death compared to those with DVT alone.