Key result
In patients with arterial hypertension, carriers of the Asn198Asn genotype of the endothelin-1 gene had significantly higher left ventricular mass compared to Lys198Lys carriers.
Why the study?
The study investigated the relationship of left ventricular hypertrophy indexes with the Lys198Asn polymorphism of the endothelin-1 gene and BMI in arterial hypertension.
Does the Lys198Asn polymorphism of the endothelin-1 gene and obesity affect left ventricular hypertrophy indices in patients with arterial hypertension?
Observational (n=160)
No
Does the Lys198Asn polymorphism of the endothelin-1 gene and obesity affect left ventricular hypertrophy indices in patients with arterial hypertension?
The Asn198Asn genotype of the endothelin-1 gene and obesity are associated with increased left ventricular mass and hypertrophy indices in patients with arterial hypertension.
May support genetic stratification for LVH risk in hypertension; leaves open causal role of endothelin-1 variants.
OBJECTIVE: The aim of the study was to find dependence of left ventricular hypertrophy indexes to polymorphism of Les198Asn gene endothelin-1 and BMI. PATIENTS AND METHODS: Materials and methods: We took research in 160 patients with arterial hypertension, using ECG and polymerase chain reaction (PCR). Groups were divided additionally according to BMI (body mass index). RESULTS: Results: It was found, that patients with obesity had their Left ventricular mass and hypertrophy left ventricular indexes higher, than in patients with normal and increased body weight. Carriers of Asn198Asn and Lys198Asn genotypes Left ventricular mass and hypertrophy left ventricular indexes are higher than in carriers of Lys198Lys genotype. CONCLUSION: Conclusions: It was determined that in patients-carriers of Asn198Asn genotype, Left ventricular mass (LVMI) and hypertrophy left ventricular indexes (LVMMI) were higher compared to patients-carriers of Lys198Lys and Lys198Asn type, both in men and women. The dependence of LVMI and LVMMI are shown to be higher in patients with obesity than in people with normal and increased body mass.
No takes yet. Share an insight, caveat, or question.
Smiianova et al. (2020) conducted an observational in Arterial hypertension (n=160). Asn198Asn genotype of endothelin-1 gene vs. Lys198Lys genotype was evaluated on Left ventricular mass (LVMM) in grams (p=0.001). In patients with arterial hypertension, carriers of the Asn198Asn genotype of the endothelin-1 gene had significantly higher left ventricular mass compared to Lys198Lys carriers.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: