What question did this study set out to answer?

To determine whether sudden fatal pulmonary embolism displays predictable chronobiological rhythms across daily (circadian) and seasonal (circannual) cycles.

May 1, 1992European Heart Journal

Sudden death from pulmonary thromboembolism: Chronobiological aspects

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Authors

MGMassimo GalleraniArcispedale Sant'Anna RMRoberto ManfrediniGeneral Cardiology LRLuciano RicciUniversity of Ferrara

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Implication

Autopsy study reveals significant morning and winter peaks in fatal pulmonary embolism among out-of-hospital deaths, highlighting time-dependent clinical risk.

Key Points

To determine whether sudden fatal pulmonary embolism displays predictable chronobiological rhythms across daily (circadian) and seasonal (circannual) cycles.
Analyzed 507 consecutive out-of-hospital sudden death cases presenting to an emergency department between January 1983 and December 1989.
Identified 48 autopsy-confirmed pulmonary embolism deaths (23 males, mean age 73.9 ± 8 years; 25 females, mean age 76 ± 12 years) with verified times and dates of death.
Assessed periodicity and acrophases using single cosinor statistical analysis.
Circadian analysis revealed a significant rhythmicity for pulmonary embolism deaths, with an acrophase peaking in the morning at 11:46 (P = 0.003).
Circannual analysis demonstrated significant seasonal rhythmicity, with a peak acrophase occurring during the winter season (-19.3°, P = 0.009).

Cite This Study

Gallerani et al. (1992) studied this question.

synapsesocial.com/papers/6a916cfe388f32339cd2d05d https://doi.org/10.1093/oxfordjournals.eurheartj.a060232

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Implication

Autopsy study reveals significant morning and winter peaks in fatal pulmonary embolism among out-of-hospital deaths, highlighting time-dependent clinical risk.

Sudden death from pulmonary thromboembolism: Chronobiological aspects

Discussion

Member takes

Implication

Key Points

Cite This Study

Sudden death from pulmonary thromboembolism: Chronobiological aspects

Discussion

Member takes

Implication

Key Points

Cite This Study

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