Key result
Higher energy defibrillation shocks (1-J or 2-J) significantly impaired ventricular contractility and intracellular Ca2+ dynamics in rat myocytes.
Why the study?
Does high-energy defibrillation impair myocyte contractility and intracellular calcium dynamics in rat ventricular myocytes?
Population
Ventricular myocytes from male Sprague-Dawley rat hearts
Comparison
Single biphasic shock of 0.5-J, 1-J, or 2-J vs Control group without shock
Design
Preclinical, Randomized
Follow-up
4 mins
Authors
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High-energy shocks may impair rat myocyte function; leaves open human relevance and optimal defibrillation energy selection.
RCT
Randomized
Does high-energy defibrillation impair myocyte contractility and intracellular calcium dynamics in rat ventricular myocytes?
Higher defibrillation energy significantly impairs ventricular contractility and intracellular calcium dynamics at the myocyte level.
Ristagno et al. (2008) conducted an RCT in Ventricular myocytes. Biphasic shock vs. Control group without shock was evaluated on Myocyte contractility and intracellular Ca2+ dynamics. Higher energy defibrillation shocks (1-J or 2-J) significantly impaired ventricular contractility and intracellular Ca2+ dynamics in rat myocytes.
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