Key result
The SHR-A3 genotype was associated with significantly higher systolic blood pressure compared to SHR-B2 (205.7 vs 186.7 mm Hg, P<10^-6), mapping to a specific locus on chromosome 17.
Population
16- to 18-week-old spontaneously hypertensive rats fed a normal diet
Comparison
High-resolution identity by descent mapping and… vs Comparison between SHR-A3 and SHR-B2 lines
Design
Preclinical
Authors
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Supports chromosome 17 locus for hypertension in SHR-A3 rats; hypothesis-generating and leaves open human translation.
Absolute Event Rate: 205.7% vs 186.7%
p-value: p=<10(-6)
High-resolution genetic mapping in spontaneously hypertensive rats identified a specific locus on chromosome 17 that contributes to elevated blood pressure in the stroke-prone SHR-A3 line.
Bell et al. (2011) studied Hypertension (n=276). SHR-A3 genotype vs. SHR-B2 genotype was evaluated on Systolic blood pressure (SBP) (p=<10(-6)). The SHR-A3 genotype was associated with significantly higher systolic blood pressure compared to SHR-B2 (205.7 vs 186.7 mm Hg, P<10^-6), mapping to a specific locus on chromosome 17.