Key result
Electrical induced ventricular fibrillation and resuscitation in piglets resulted in significantly reduced segmental wall motion in the LAD territory (3.31 vs 4.68 mm at baseline, p=0.0026).
Why the study?
Does ventricular fibrillation-induced cardiac arrest cause preferential regional cardiac injury in a piglet model?
RCT (n=12)
randomized
Does ventricular fibrillation-induced cardiac arrest cause preferential regional cardiac injury in a piglet model?
Absolute Event Rate: 3.31% vs 4.68%
p-value: p=0.0026
Ventricular fibrillation-induced cardiac arrest results in preferential segmental wall motion defects in the LAD territory without perfusion defects in a piglet model.
VF arrest may preferentially impair LAD territory function in piglets; leaves open human relevance and need for clinical validation.
Objective. Decreased cardiac function after resuscitation from cardiac arrest (CA) results from global ischemia of the myocardium. In the evolution of postarrest myocardial dysfunction, preferential involvement of any coronary arterial territory is not known. We hypothesized that there is no preferential involvement of any coronary artery during electrical induced ventricular fibrillation (VF) in piglet model. Design. Prospective, randomized controlled study. Methods. 12 piglets were randomized to baseline and electrical induced VF. After 5 min, the animals were resuscitated according to AHA PALS guidelines. After return of spontaneous circulation (ROSC), animals were observed for an additional 4 hours prior to cardiac MRI. Data (mean ± SD) was analyzed using unpaired t-test; p value ≤ 0.05 was considered statistically significant. Results. Segmental wall motion (mm; baseline versus postarrest group) in segment 7 (left anterior descending (LAD)) was 4.68±0.54 versus 3.31±0.64 , p=0.0026 . In segment 13, it was 3.82±0.96 versus 2.58±0.82 , p=0.02 . In segment 14, it was 2.42±0.44 versus 1.29±0.99 , p=0.028 . Conclusion. Postarrest myocardial dysfunction resulted in segmental wall motion defects in the LAD territory. There were no perfusion defects in the involved segments.
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Venkata et al. (2016) conducted an RCT in Cardiac arrest (n=12). Electrical induced ventricular fibrillation and resuscitation vs. Baseline was evaluated on Segmental wall motion in segment 7 (left anterior descending territory) (p=0.0026). Electrical induced ventricular fibrillation and resuscitation in piglets resulted in significantly reduced segmental wall motion in the LAD territory (3.31 vs 4.68 mm at baseline, p=0.0026).
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