Key result
Severe baseline right ventricular dysfunction (TAPSE ≤14 mm) was associated with a lower rate of left ventricular reverse remodeling 6 months after CRT compared to TAPSE >14 mm (14% vs 76%, P<0.001).
Why the study?
Does baseline right ventricular function predict echocardiographic response to cardiac resynchronization therapy in patients with heart failure?
Observational (n=44)
Does baseline right ventricular function predict echocardiographic response to cardiac resynchronization therapy in patients with heart failure?
Absolute Event Rate: 14% vs 76%
p-value: p=<0.001
Severe baseline right ventricular dysfunction is associated with a significantly lower likelihood of left ventricular reverse remodeling following cardiac resynchronization therapy.
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Severe RV dysfunction may limit CRT remodeling response; leaves open whether RV assessment should guide selection.
Scuteri et al. (2009) conducted an observational in Heart failure (n=44). Severe right ventricular dysfunction (TAPSE ≤14 mm) vs. TAPSE >14 mm was evaluated on Significant LV reverse remodeling (LVESV reduction ≥15% at 6 months) (p=<0.001). Severe baseline right ventricular dysfunction (TAPSE ≤14 mm) was associated with a lower rate of left ventricular reverse remodeling 6 months after CRT compared to TAPSE >14 mm (14% vs 76%, P<0.001).