Key result
In young Caucasian men, the presence of the minor rs168924 G allele in the SLC6A2 gene was significantly associated with a lower prevalence of hypertension (OR 0.48).
Why the study?
Does the rs168924 polymorphism in the SLC6A2 gene affect blood pressure and hypertension prevalence in young Caucasian men?
Cross-Sectional (n=282)
No
Does the rs168924 polymorphism in the SLC6A2 gene affect blood pressure and hypertension prevalence in young Caucasian men?
Odds Ratio: 0.48 (95% CI 0.23–0.98)
p-value: p=0.044
The minor G allele of the rs168924 polymorphism in the SLC6A2 gene is associated with lower blood pressure and a reduced prevalence of hypertension in young Caucasian men, contrasting with previous findings in Japanese populations.
The rs168924 G allele was associated with lower hypertension prevalence in young Caucasian men; leaves open ethnic generalizability and prospective validation.
The NG_016969.1:g.5003A>G promoter polymorphism (rs168924) in the SLC6A2 norepinephrine transporter gene was found to be predictive of the hypertensive status in a Japanese population, but no data are available for Caucasians. Genotyping for rs168924 was performed in 282 young men with normal blood pressure (BP), grade 1 or 2 hypertension. In addition to casual BP, 24-hour ABPM and echocardiography were performed. Multiple regression analysis revealed a significant association of rs168924 genotype with diagnosis of hypertension (P=.044), casual systolic BP (SBP) levels (P=.028), and daytime ambulatory SBP (P=.02). The finding that rs168924 was also significantly associated with diastolic posterior wall thickness (P=.041), an echocardiographic index of hypertensive cardiac target organ damage, further supports the notion that the rs168924 SNP in SLC6A2 in fact might influence BP. Unlike previous findings in a Japanese population, in our Caucasian study cohort the presence of the minor rs168924 G allele was associated with lower prevalence of hypertension.
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Zolk et al. (2012) conducted a cross-sectional in Essential hypertension (n=282). rs168924 G allele in the SLC6A2 gene vs. rs168924 AA genotype was evaluated on Diagnosis of hypertension (OR 0.48, 95% CI 0.23-0.98, p=0.044). In young Caucasian men, the presence of the minor rs168924 G allele in the SLC6A2 gene was significantly associated with a lower prevalence of hypertension (OR 0.48).
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