Key result
Although guinea pig ventricular myocytes possess NOS activity, NO production does not play an important role in muscarinic inhibition of beta-adrenergically regulated Cl- channels in these cells.
Population
Guinea pig ventricular myocytes
Design
Preclinical
Authors
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NO does not mediate muscarinic Cl- inhibition in guinea pig ventricular myocytes; challenges uniform NO role across cardiac cell types and leaves open species-specific mechanisms.
Contrary to sinoatrial node cells, nitric oxide production does not mediate muscarinic inhibition of beta-adrenergically regulated chloride channels in guinea pig ventricular myocytes.
Zakharov et al. (1996) studied this question. Nitric oxide (NO) donors and NOS inhibitors was evaluated on Muscarinic inhibition of beta-adrenergically regulated Cl- channels. Although guinea pig ventricular myocytes possess NOS activity, NO production does not play an important role in muscarinic inhibition of beta-adrenergically regulated Cl- channels in these cells.
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