Key result
Immunohistochemical staining revealed significant differences in the abundance and distinct distribution patterns of A1, A2A, A2B, and A3 receptors between rat abdominal aorta and tail arteries.
The distinct distribution patterns of adenosine receptor subtypes in elastic versus muscular arteries provide an anatomical basis for their differential roles in regulating vascular tone and blood flow.
Suggests vessel-specific adenosine signaling in rats; leaves open translation to human vascular regulation and therapy.
Adenosine plays an important role in the cardiovascular system, activating adenosine A(1), A(2A), A(2B), and A(3) receptors, and regulating blood flow either by acting directly on vascular cells or indirectly because of its effects on the central or peripheral nervous systems. The aim of the present study was to investigate whether the pattern of distribution of adenosine receptor subtypes is different on elastic and muscular, using abdominal aorta and tail arteries as models. Immunohistochemistry using anti-A(1), anti-A(2A), anti-A(2B), and anti-A(3) receptor antibodies was performed on perfused-fixed/paraffin-embedded arteries from Wistar rats. 3,3'-Diaminobenzidine tetrahydrochloride (DAB; activated by hydrogen peroxide) staining revealed significant differences in the abundance of A(1), A(2A), and A(3) receptors between abdominal aorta and tail artery and allowed the identification of distinct distribution patterns for A(1), A(2A), A(2B), and A(3) receptors in the tunica adventitia, media, and intima of muscular and elastic arteries. Data are compatible with several previous functional reports supporting that different adenosine receptor subtype expression and/or their distribution in the vessel wall may influence their respective contribution to the control of blood flow.
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Leal et al. (2008) studied this question. Immunohistochemistry using anti-adenosine receptor antibodies was evaluated on Distribution of adenosine receptor subtypes (A1, A2A, A2B, A3) in elastic and muscular arteries. Immunohistochemical staining revealed significant differences in the abundance and distinct distribution patterns of A1, A2A, A2B, and A3 receptors between rat abdominal aorta and tail arteries.
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