Key result
Application of anthracene-9-carboxylic acid (500 micro M) inhibited maximum outward Cl- current at +70 mV by 21+/-10% but augmented instantaneous inward relaxation at -80 mV by 321+/-34%.
Why the study?
Does anthracene-9-carboxylic acid alter Ca(2+)-activated Cl(-) currents in rabbit pulmonary artery smooth muscle cells?
Does anthracene-9-carboxylic acid alter Ca(2+)-activated Cl(-) currents in rabbit pulmonary artery smooth muscle cells?
Anthracene-9-carboxylic acid anomalously augments inward Ca(2+)-activated Cl(-) currents at negative membrane potentials following depolarization in rabbit pulmonary artery smooth muscle cells.
Authors
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Anomalous inward Cl- current augmentation by 9-AC in rabbit cells; leaves open its selectivity as a vascular Cl- blocker.
Piper et al. (2003) studied this question. Anthracene-9-carboxylic acid (A-9-C) vs. Absence of A-9-C was evaluated on Calcium-activated chloride currents. Application of anthracene-9-carboxylic acid (500 micro M) inhibited maximum outward Cl- current at +70 mV by 21+/-10% but augmented instantaneous inward relaxation at -80 mV by 321+/-34%.
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