May 1, 1990British Journal of PharmacologyOpen Access

Demonstration of extrapulmonary activity of angiotensin converting enzyme in intact tissue preparations

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Population

Intact isolated preparations of extrapulmonary tissues

Design

Preclinical

Authors

FLF. LembeckCharité - Universitätsmedizin Berlin TGThomas GriesbacherUniversity of Graz MEMartin EckhardtMedical University of Vienna

Discussion

Member takes

Implication

Animal data on tissue ACE activity require human validation; leaves open contribution of extrapulmonary ACE to bradykinin and angiotensin effects in vivo.

Structured PICO

Population

Intact isolated preparations of extrapulmonary tissues (rat isolated uterus, guinea-pig ileum, isolated perfused ear of the rabbit, rat isolated colon, pithed rats)

Intervention

Captopril (specific inhibitor of ACE)

Outcome

Conversion of angiotensin I to angiotensin II and the cleavage of bradykinin (measured by functional parameters like contractions and vasoconstriction)surrogate

Demonstrates high ACE activity in the endothelium of extrapulmonary blood vessels, suggesting a local endothelium-dependent vasoconstrictor mechanism.

Cite This Study

Lembeck et al. (1990) studied this question.

synapsesocial.com/papers/6a917f1487dfe5d232f13d9a https://doi.org/10.1111/j.1476-5381.1990.tb12050.x

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Implication

Animal data on tissue ACE activity require human validation; leaves open contribution of extrapulmonary ACE to bradykinin and angiotensin effects in vivo.

Demonstration of extrapulmonary activity of angiotensin converting enzyme in intact tissue preparations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Demonstration of extrapulmonary activity of angiotensin converting enzyme in intact tissue preparations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider