Why the study?
Does neonatal thymectomy alter the clinical and virological response to intracerebral inoculation with subacute sclerosing panencephalitis virus in adult hamsters?
Population
Syrian golden hamsters, over 12 weeks old, inoculated intracerebrally with the HBS strain of hamster-adapted…
Comparison
Neonatal thymectomy vs Hamsters with histologically identifiable…
Design
Preclinical
Follow-up
Up to 35 days postinoculation
Authors
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Thymus-dependent immunity may be required to clear CNS measles virus in hamsters; leaves open its role in human SSPE pathogenesis.
Does neonatal thymectomy alter the clinical and virological response to intracerebral inoculation with subacute sclerosing panencephalitis virus in adult hamsters?
In a hamster model, the immune system (specifically thymus-dependent responses) is essential for recovering from central nervous system measles infection and preventing subacute sclerosing panencephalitis.
Johnson et al. (1975) studied this question.
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