Pathogenesis of Allergic Inflammation With Participation of Il-17 and Il-23 Cytokines in Patients With Chronic Epstein-Barr Virus Persistence in Active and Latent Phases

The biological properties of IL-23 are well-known for its ability to enhance Th17 cells functions, in particular their proliferation and production of IL-17. By affecting Th17 lymphocytes, IL-23 contributes to development and chronicity of inflammatory conditions and diseases, primarily autoimmune diseases. Allergic asthma is considered to be a Th2-dominant chronic inflammatory disease of the lungs. In patients with asthma are observed activation of Th2cells, an increase in production of cytokines with subsequent pathogenetic effects. It is well known that viruses including the Herpesviridaeus family can be a trigger of different allergic conditions. It was suggested that the ability of IL-23 to induce the production of IL-17A and IL-17F may indicate its involvement in the pathogenesis of allergic diseases, including virus-induced. The aim of our work was to investigate the role of IL-17and IL-23 cytokines in the . IL23 Th17-, IL17. Th17-, IL23 , , , . Th2- . Th2- . , , , . , IL23 IL17A IL17F , .. . IL17 IL23 - . . 38 -, (32,73,2) . , - . IL17 IL23 - (1- , 20 ) (2- , 18 ) . 20 . . -