Key result
Hostility was positively correlated with fasting glucose in African American women, and this association was significantly reduced after controlling for central nervous system serotonin function.
Why the study?
Does central nervous system serotonin influence the association between hostility and fasting glucose in African American women?
Cross-Sectional (n=119)
Does central nervous system serotonin influence the association between hostility and fasting glucose in African American women?
Central nervous system serotonin function partly explains the positive correlation between hostility and fasting glucose in African American women.
Answers are grounded in this paper and cite their sources.
Supports serotonin as a research target in glucose dysregulation; hypothesis-generating and should not yet change practice.
BACKGROUND: Previous research has shown an association between hostility and fasting glucose in African American women. Central nervous system serotonin activity is implicated both in metabolic processes and in hostility related traits. PURPOSE: The purpose of this study is to determine whether central nervous system serotonin influences the association between hostility and fasting glucose in African American women. METHODS: The study consisted of 119 healthy volunteers (36 African American women, 27 White women, 21 White males, and 35 African American males, mean age 34 ± 8.5 years). Serotonin related compounds were measured in cerebrospinal fluid. Hostility was measured by the Cook-Medley Hostility Scale. RESULTS: Hostility was associated with fasting glucose and central nervous system serotonin related compounds in African American women only. Controlling for the serotonin related compounds significantly reduced the association of hostility to glucose. CONCLUSIONS: The positive correlation between hostility and fasting glucose in African American women can partly be explained by central nervous system serotonin function.
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Boyle et al. (2014) conducted a cross-sectional in Healthy volunteers (n=119). Hostility and central nervous system serotonin was evaluated on Association between hostility and fasting glucose. Hostility was positively correlated with fasting glucose in African American women, and this association was significantly reduced after controlling for central nervous system serotonin function.
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