Key result
Folic acid administration reduced total homocysteine levels from 18 to 12 micromol/L, improving cardiac remodeling and endocardial endothelial function in spontaneously hypertensive rats.
Why the study?
Does folic acid improve cardiac remodeling and endocardial endothelial function in homocysteinemic hypertensive rats?
Population
Spontaneously hypertensive rats with moderately high endogenous total homocystine levels and control age…
Comparison
Folic acid administration or Homocysteine 32… vs Untreated spontaneously hypertensive rats and…
Design
Preclinical
Follow-up
12 weeks
Authors
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Hypothesis-generating in hypertensive rat models; leaves open any cardiac benefit of homocysteine lowering in humans.
Does folic acid improve cardiac remodeling and endocardial endothelial function in homocysteinemic hypertensive rats?
Folic acid improves cardiac remodeling and endocardial endothelial function in homocysteinemic hypertensive rats, suggesting a differential role of homocysteine isomers in vascular versus cardiac remodeling.
Miller et al. (2002) studied Hypertension and hyperhomocysteinemia. Folic acid and Homocysteine vs. Control normotensive Wistar rats and untreated spontaneously hypertensive rats was evaluated on Endocardial endothelial function, cardiac remodeling, and total homocysteine levels. Folic acid administration reduced total homocysteine levels from 18 to 12 micromol/L, improving cardiac remodeling and endocardial endothelial function in spontaneously hypertensive rats.
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