Key result
The platelet glycoprotein Ia 807 TT genotype was associated with an increased risk of acute coronary syndrome compared with C-allele carriers (OR 2.9; 95% CI 1.4-5.8).
Why the study?
Does the GP Ia 807 TT genotype increase the risk of acute coronary syndrome in the Italian population?
Population
469 individuals of Italian ancestry, comprising 157 patients with acute coronary syndrome as the first…
Comparison
Presence of the GP Ia 807 TT (873 AA) genotype vs C-allele carriers or 807 CC (873 GG) genotype
Design
Case-control
Authors
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Hypothesis-generating for genetic ACS risk in Italians; prospective validation needed before clinical adoption.
Case-Control (n=469)
Does the GP Ia 807 TT genotype increase the risk of acute coronary syndrome in the Italian population?
Odds Ratio: 2.9 (95% CI 1.4–5.8)
Absolute Event Rate: 12.7% vs 4.8%
The GP Ia 807 TT genotype is a significant genetic risk factor for early-onset acute coronary syndrome in the Italian population.
Casorelli et al. (2001) conducted a case-control in Acute coronary syndrome (n=469). GP Ia 807 TT genotype vs. C-allele carriers was evaluated on Acute coronary syndrome (OR 2.9, 95% CI 1.4-5.8). The platelet glycoprotein Ia 807 TT genotype was associated with an increased risk of acute coronary syndrome compared with C-allele carriers (OR 2.9; 95% CI 1.4-5.8).
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