Key result
Platelet collagen receptor polymorphisms GP Ia C807T and GP VI T13254C were not significantly associated with premature acute myocardial infarction (P=0.08 and P=0.46, respectively).
Why the study?
Are platelet collagen receptor polymorphisms (GP VI T13254C and GP Ia C807T) associated with premature acute myocardial infarction?
Case-Control (n=200)
Are platelet collagen receptor polymorphisms (GP VI T13254C and GP Ia C807T) associated with premature acute myocardial infarction?
Platelet collagen receptor polymorphisms GP VI T13254C and GP Ia C807T do not appear to be associated with premature acute myocardial infarction.
Answers are grounded in this paper and cite their sources.
No association found in this case-control study; leaves open any role of these polymorphisms in premature MI and requires larger prospective confirmation.
The impact of platelet collagen receptor polymorphisms in the pathogenesis of myocardial infarction at young age remains unknown. To determine whether either of the two platelet collagen receptor polymorphisms (GP VI T13254C and GP Ia C807T) was associated with premature acute myocardial infarction. One hundred patients with premature acute myocardial infarction and 100 age-matched controls with normal coronary angiograms were studied. Genotyping was done using PCR followed by restriction fragment length polymorphism (RFLP). GP Ia C807T polymorphism was more frequent in the patient group (65%) than in the control group (53%). However, there was no association between this polymorphism and premature acute myocardial infarction (P = 0.08). The prevalence of T13254C polymorphism did not differ between patients (38%) and controls (33%), and this polymorphism was not associated with premature acute myocardial infarction (P = 0.46). Logistic regression analysis also indicated no association between these polymorphisms and premature acute myocardial infarction (C807T with P = 0.51 and T13254C with P = 0.20). There is no association between GP VI T13254C or GP Ia C807T polymorphisms and premature acute myocardial infarction.
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Kazemi et al. (2012) conducted a case-control in Premature acute myocardial infarction (n=200). Platelet collagen receptor polymorphisms (GP VI T13254C and GP Ia C807T) vs. Controls with normal coronary angiograms was evaluated on Premature acute myocardial infarction (p=0.08). Platelet collagen receptor polymorphisms GP Ia C807T and GP VI T13254C were not significantly associated with premature acute myocardial infarction (P=0.08 and P=0.46, respectively).
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