Why the study?
Does the GPIa A1648G gene polymorphism influence the risk of CAD and AMI in male Caucasian patients undergoing coronary angiography?
Population
2163 male Caucasian patients who underwent coronary angiography
Comparison
GPIa A1648G (Br, HPA-5) gene polymorphism vs Different genotypes
Design
Cross-sectional
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Subgroup association in low-risk patients should not change practice; leaves open effect modification by lipids and smoking in CAD risk.
Does the GPIa A1648G gene polymorphism influence the risk of CAD and AMI in male Caucasian patients undergoing coronary angiography?
The GPIa A1648G polymorphism is associated with the risk and extent of CAD specifically in low-risk patient subgroups, such as non-smokers with a favorable lipid profile.
A 2000 study studied this question.
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