Key result
The platelet membrane GPIa TC genotype was associated with significantly higher plasma GMP-140 levels and a shorter lag-time for collagen-induced platelet aggregation compared to the CC genotype.
Why the study?
Does the platelet membrane GPIa gene 807C/T polymorphism affect platelet aggregation and GMP-140 levels in patients with unstable angina pectoris?
Case-Control (n=68)
Does the platelet membrane GPIa gene 807C/T polymorphism affect platelet aggregation and GMP-140 levels in patients with unstable angina pectoris?
The platelet membrane GPIa T807 allele is associated with more rapid initiation of collagen-induced platelet aggregation and higher GMP-140 levels, suggesting a mechanistic role in the pathogenesis of unstable angina pectoris.
May link GPIa polymorphism to platelet hyperactivity in unstable angina; hypothesis-generating and should not yet change practice.
The functional effect of platelet membrane glycoprotein Ia (GPIa) gene 807C/T polymorphism in unstable angina pectoris (UAP) pathogenesis was investigated in Chinese Han individuals. Collagen type I-induced platelet aggregation was measured in 33 healthy subjects. Plasma levels of α-granule membrane protein (GMP-140) were measured in 33 healthy subjects and in 35 patients with recent-onset angina at rest within 24 h of hospitalization. Platelet membrane GPIa gene 807C/T polymorphism was determined in all subjects. Lag-time before 30% platelet aggregation was significantly longer in CC genotype than in TC genotype healthy subjects, although there was no significant difference in maximal platelet aggregation between healthy subjects with either genotype. Plasma GMP-140 levels were significantly higher in TC genotype patients compared with CC genotype patients or healthy subjects; a significant difference was also observed between the latter two groups. It was concluded that rapid initiation of collagen-induced platelet aggregation may be associated with the platelet membrane GPIa T807 allele, which may be important in UAP pathogenesis.
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Zhao et al. (2011) conducted a case-control in Unstable angina pectoris (n=68). Platelet membrane GPIa gene 807C/T polymorphism (TC genotype) vs. CC genotype was evaluated on Lag-time before 30% platelet aggregation and plasma GMP-140 levels. The platelet membrane GPIa TC genotype was associated with significantly higher plasma GMP-140 levels and a shorter lag-time for collagen-induced platelet aggregation compared to the CC genotype.
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