Key result
MRS2179 selectively antagonized P2Y1 receptor-mediated vasodilation induced by 2-MeS-ATP, ADP, and ATP in guinea-pig aorta, while having no effect on UTP-induced relaxation.
Population
Guinea-pig thoracic aorta (aortic rings and primary cultured aortic endothelial cells)
Design
Preclinical
Authors
Loading...
May aid preclinical vascular research; leaves open translation of P2Y1 antagonism to human therapy.
MRS2179 acts as a selective P2Y1 receptor antagonist, blocking purine-mediated vasodilation and calcium release in guinea-pig aorta.
Kaiser et al. (2002) studied Vascular tone regulation (animal model). MRS2179 vs. Vehicle/Baseline was evaluated on Inhibition of nucleotide-mediated relaxation of norepinephrine-induced contraction. MRS2179 selectively antagonized P2Y1 receptor-mediated vasodilation induced by 2-MeS-ATP, ADP, and ATP in guinea-pig aorta, while having no effect on UTP-induced relaxation.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: