Key result
In adrenergically stimulated rabbits, azimilide resulted in significantly less time spent in sustained and nonsustained ventricular tachyarrhythmias compared to dofetilide, clofilium, and sematilide.
In a rabbit model, azimilide demonstrated a lower proarrhythmic burden (less time in SVT/NSVT) compared to other class III antiarrhythmics at equivalent QTc-prolonging doses.
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Azimilide's lower arrhythmia burden in this rabbit model suggests class III heterogeneity; leaves open clinical translation pending human trials.
Brooks et al. (2000) studied Ventricular proarrhythmia (animal model). Azimilide, clofilium, dofetilide, sematilide, and d,l-sotalol vs. Compared against each other was evaluated on Proportion of time spent in sustained and combined nonsustained and sustained ventricular tachyarrhythmias. In adrenergically stimulated rabbits, azimilide resulted in significantly less time spent in sustained and nonsustained ventricular tachyarrhythmias compared to dofetilide, clofilium, and sematilide.
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