Key result
In adrenergically stimulated rabbits, azimilide resulted in significantly less time spent in sustained and nonsustained ventricular tachyarrhythmias compared to other class III antiarrhythmics.
In a rabbit model, azimilide showed a lower burden of sustained and nonsustained ventricular tachyarrhythmias compared to other class III antiarrhythmic agents at equivalent QTc-prolonging doses.
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May support azimilide differentiation in adrenergic models; leaves open human translation and clinical testing.
Brooks et al. (2000) studied Adrenergically stimulated anesthetized rabbits. Azimilide, clofilium, dofetilide, sematilide, and d,l-sotalol vs. Compared against each other was evaluated on Proportion of time treated rabbits spent in SVT and combined NSVT and SVT. In adrenergically stimulated rabbits, azimilide resulted in significantly less time spent in sustained and nonsustained ventricular tachyarrhythmias compared to other class III antiarrhythmics.
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