Why the study?
What is the natural course and hemodynamic transformation of ventricular septal defects in infants over time?
Population
336 patients with ventricular septal defects, including 27 who underwent autopsy and 10 infants restudied…
Design
Case_series
Follow-up
3 to 5 years
Authors
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Case reports of VSD evolving to tetralogy of Fallot or stenotic defects; hypothesis-generating for natural history frequency.
What is the natural course and hemodynamic transformation of ventricular septal defects in infants over time?
The study demonstrates that ventricular septal defects can naturally transform into other entities such as VSD with infundibular stenosis or tetralogy of Fallot over time.
Benjamin M. Gasul (1957) studied this question.
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