Key result
In patients with type 2 diabetes, albuminuria was an independent predictor for cardio ankle vascular index (P=0.002) and positively correlated with it (r=0.285), but not associated with BaPWV.
Why the study?
Is albuminuria associated with increased arterial stiffness (BaPWV and CAVI) in patients with type 2 diabetes?
Observational (n=106)
Is albuminuria associated with increased arterial stiffness (BaPWV and CAVI) in patients with type 2 diabetes?
Effect estimate: r = 0.285
p-value: p=0.002
In patients with type 2 diabetes, albuminuria is an independent predictor of arterial stiffness as measured by CAVI.
Albuminuria may inform CAVI-based vascular risk assessment in type 2 diabetes; hypothesis-generating and requires prospective validation before practice change.
Background: Brachial ankle pulse wave velocity (BaPWV) and cardio ankle vascular index (CAVI), as indicators of arterial stiffness, are increased in type 2 diabetes. Albuminuria, as a cardiovascular risk factor in type 2 diabetes, can cause endothelial dysfunction and atherosclerosis, and these can increase arterial stiffness. So we investigated the hypothesis that increased albuminuria reflects increased BaPWV and CAVI in type 2 diabetes. Methods: We retrospectively analyzed 106 patients (58 men and 48 women) with type 2 diabetes from March 2005 to September 2006. Urine albumin creatinine ratio (ACR) to evaluate urinary albumin excretion, BaPWV and CAVI were measured in all patients. Results: All patients were divided 3 groups, normal group (ACR 300 mg/g Cr., n = 33). BaPWV and CAVI in microalbuminuria group and proteinuria group are faster than normal group. In bivariate correlation analysis, BaPWV was not associated with ACR, but CA VI was positively correlated to ACR (r = 0.285, P = 0.003). BaPWV was positively correlated to age, diabetes duration, body mass index, systolic blood pressure, diastolic pressure, pulse pressure and negatively correlated to glomerular filtration rate (GFR). CAVI was positively correlated to age, diabetes duration and negatively correlated to GFR. In multiple linear stepwise regression analysis, BaPWV was not associated with ACR, but ACR was independent predictor for CAVI (P = 0.002). Conclusion: In type 2 diabetes, albuminuria was independent predictor for indicators of arterial stiffness,
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Lee et al. (2007) conducted an observational in Type 2 diabetes (n=106). Albuminuria vs. Normal urinary albumin excretion was evaluated on Cardio ankle vascular index (CAVI) (r = 0.285, p=0.002). In patients with type 2 diabetes, albuminuria was an independent predictor for cardio ankle vascular index (P=0.002) and positively correlated with it (r=0.285), but not associated with BaPWV.
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