Key result
Serum triglyceride levels ≥5.65 mmol/L at 48 hours of admission were independently associated with increased development of persistent organ failure (OR 3.316; 95% CI 1.256-8.755; P=0.016).
Why the study?
The study was designed to examine the relationship between the reduction of serum triglycerides and disease severity in patients with hypertriglyceridemic pancreatitis.
Does timely reduction of serum triglycerides reduce persistent organ failure in patients with hypertriglyceridemic pancreatitis?
Cohort (n=242)
Does timely reduction of serum triglycerides reduce persistent organ failure in patients with hypertriglyceridemic pancreatitis?
Odds Ratio: 3.316 (95% CI 1.256–8.755)
p-value: p=0.016
Timely reduction of serum triglycerides to <5.65 mmol/L within 48 hours of admission is associated with a decreased risk of persistent organ failure in patients with hypertriglyceridemic pancreatitis.
Early TG reduction by 48 h was associated with lower POF risk in HTGP; leaves open whether targeted lowering improves outcomes.
OBJECTIVES: The aim of the study was to examine the relationship between the reduction of serum triglycerides (TGs) and the severity of disease in patients with hypertriglyceridemic pancreatitis (HTGP). METHODS: A retrospective study was conducted among patients with HTGP. Serum TGs measured on admission (TG0), 24 hours after admission (TG24), and 48 hours after admission (TG48) were compared between patients with and without persistent organ failure (POF). Multivariable analysis determined whether elevated TG levels were independently associated with POF. RESULTS: A total of 242 patients were included, of which 62 patients (25.6%) developed POF. Patients who developed POF had higher TG levels of TG0, TG24, and TG48 than those without POF (all P < 0.05). Patients with earlier TG levels of less than 5.65 mmol/L were proportionally less likely to develop POF (Ptrend = 0.002). On multivariate analysis, TG48 of 5.65 mmol/L or more was independently associated with POF (odds ratio, 3.316; 95% confidence interval, 1.256-8.755; P = 0.016). CONCLUSIONS: Timely reduction of serum TGs during the early phase of HTGP is proportionally associated with decreased development of POF. Serum TG levels by 48 hours of admission correlate independently with POF.
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Lu et al. (2019) conducted a cohort in Hypertriglyceridemic pancreatitis (n=242). Serum triglyceride levels ≥5.65 mmol/L at 48 hours vs. Serum triglyceride levels <5.65 mmol/L at 48 hours was evaluated on Persistent organ failure (POF) (OR 3.316, 95% CI 1.256-8.755, p=0.016). Serum triglyceride levels ≥5.65 mmol/L at 48 hours of admission were independently associated with increased development of persistent organ failure (OR 3.316; 95% CI 1.256-8.755; P=0.016).
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