Key result
Aged garlic extract and grape seed proanthocyanidin demonstrated protective effects against doxorubicin-induced cardiac injury on electron microscopy, despite unclear effects on antioxidant enzymes.
Why the study?
Do natural antioxidant foods (aged garlic extract, grape seed proanthocyanidin, and hazelnut) prevent doxorubicin-induced cardiotoxicity in a rat model?
Population
Wistar albino male rats (n=135)
Comparison
Aged garlic extract, grape seed… vs Control group receiving intraperitoneal 0.9%…
Design
Preclinical, assigned randomly
Follow-up
6 weeks
Authors
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Rat findings are hypothesis-generating; human trials needed before any clinical consideration for doxorubicin cardiotoxicity.
RCT (n=135)
randomly assigned
Do natural antioxidant foods (aged garlic extract, grape seed proanthocyanidin, and hazelnut) prevent doxorubicin-induced cardiotoxicity in a rat model?
Aged garlic extract and grape seed proanthocyanidin demonstrated protective effects against doxorubicin-induced cardiotoxicity on electron microscopy in a rat model.
Demirkaya et al. (2009) conducted an RCT in Doxorubicin-induced cardiotoxicity (n=135). Aged garlic extract, grape seed proanthocyanidin, and hazelnut vs. 0.9% saline (control) and doxorubicin alone was evaluated on Cardiac injury assessed by antioxidant enzymes (MDA, SOD, CAT, XO), creatine kinase, and electron microscopy. Aged garlic extract and grape seed proanthocyanidin demonstrated protective effects against doxorubicin-induced cardiac injury on electron microscopy, despite unclear effects on antioxidant enzymes.