Key result
Aged garlic extract pretreatment increases survival to 70% vs 30% against doxorubicin cardiotoxicity in mice.
Why the study?
The mechanisms of the cardioprotective effect of aged garlic extract against doxorubicin-induced cardiotoxicity and its impact on doxorubicin's antitumor effect were not fully understood.
Does aged garlic extract prevent doxorubicin-induced cardiotoxicity without compromising antitumor efficacy in preclinical models?
Population
Primary cultured neonatal rat cardiac myocytes and tumor-bearing mice
Comparison
Aged garlic extract pretreatment plus doxorubicin vs doxorubicin alone
Design
Preclinical experimental study
Follow-up
24 hours in vitro
Authors
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AGE may attenuate doxorubicin cardiotoxicity; leaves open clinical translation in oncology patients.
Does aged garlic extract prevent doxorubicin-induced cardiotoxicity without compromising antitumor efficacy in preclinical models?
Absolute Event Rate: 70% vs 30%
Aged garlic extract protects against doxorubicin-induced cardiotoxicity in preclinical models while potentially enhancing antitumor efficacy and survival.
Alkreathy et al. (2011) studied Doxorubicin-induced cardiotoxicity. Aged garlic extract (AGE) vs. Doxorubicin alone was evaluated on Long term survival of tumor-bearing mice. Aged garlic extract pretreatment suppressed doxorubicin-induced apoptotic cell death in cardiac myocytes and increased long-term survival of tumor-bearing mice from 30% to 70%.
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