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January 1, 1984Thrombosis and Haemostasis

Platelet Production in Myocardial Infarction and Sudden Cardiac Death

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Why the study?

Are megakaryocyte cytoplasmic volumes and platelet volumes altered in patients with myocardial infarction or coronary sudden unexpected death compared to controls?

Population

n=34 subjects, comprising 13 coronary care unit patients, 10 subjects with coronary sudden unexpected death…

Design

Case-control

Follow-up

18 +/- 2 days (for CCU subjects)

Authors

ETE. A. TrowbridgeUniversity of SheffieldDSD.N. SlaterUniversity of BradfordYKYehia T. KishkAssiut University

Discussion

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Implication

May link altered thrombopoiesis to MI and CSD; hypothesis-generating and should not yet change practice.

Structured PICO

Are megakaryocyte cytoplasmic volumes and platelet volumes altered in patients with myocardial infarction or coronary sudden unexpected death compared to controls?

P
Population
n=34 subjects, comprising 13 coronary care unit patients (7 with myocardial infarction, 6 with chest pain but no recent infarction), 10 subjects with coronary sudden unexpected death, and 11 subjects with sudden unexpected un-natural death.
C
Comparator
Control groups consisting of subjects with chest pain but no recent infarction (n=6) and subjects with sudden unexpected un-natural death (n=11).
O
Outcome
Megakaryocyte cytoplasmic volume distributions and platelet volumessurrogate

Megakaryocyte cytoplasmic volumes are significantly increased in patients with myocardial infarction and coronary sudden death compared to controls, suggesting altered platelet production in these acute coronary conditions.

Cite This Study

Trowbridge et al. (1984) studied this question.

synapsesocial.com/papers/6a91a5a35cf4c7c25387288ahttps://doi.org/10.1055/s-0038-1661165
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet Number and Volume during Myocardial Infarction in Relation to Infarct Size1986 · 36 citations
  2. 2Platelet Survival and Platelet Production in Acute Myocardial Infarction1979 · 21 citations
  3. 3Platelet size in myocardial infarction.1983 · 178 citations
  4. 4Large platelets continue to circulate in an activated state after myocardial infarction1994 · 56 citations
  5. 5High mean platelet volume after myocardial infarction: is it due to consumption of small platelets?1984 · 62 citations