Why the study?
Does the Met235-->Thr variant of the angiotensinogen gene associate with higher systolic blood pressure or family history of essential hypertension in Japanese children?
Does the Met235-->Thr variant of the angiotensinogen gene associate with higher systolic blood pressure or family history of essential hypertension in Japanese children?
The Met235-->Thr variant of the angiotensinogen gene is associated with higher systolic blood pressure in Japanese children, suggesting a genetic role in early blood pressure regulation.
Answers are grounded in this paper and cite their sources.
Met235-->Thr variant was associated with higher childhood SBP; leaves open its role in essential hypertension risk.
A recent study reported a significant relationship between a T704-->C (Met235-->Thr) variant in exon 2 of the angiotensinogen gene in adults and essential hypertension. In the present study, this variant was detected in 131 Japanese children using a polymerase chain reaction. The allele frequency of the variant was 0.76. The genotype frequency of the homozygote for the allele was 0.59, and children who were homozygous had higher systolic blood pressure than those with the other two genotypes. No relationship was found between children's polymorphism and a family history of essential hypertension. These findings suggest that this molecular variant of the angiotensinogen gene may play some role in the regulation of blood pressure in Japanese children.
No takes yet. Share an insight, caveat, or question.
Kataoka et al. (1996) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: