Key result
Mianserin overdose caused bradycardia and hypotension in a 37-year-old woman, which resolved after treatment with atropine and theophylline.
Case Report (n=1)
Mianserin intoxication can rarely cause significant bradycardia and hypotension, highlighting the need for close monitoring in overdose cases.
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Alerts clinicians to monitor for bradycardia in mianserin overdose; leaves open generalizability from this single case.
Cardiotoxicity is an important adverse effect of tricyclic antidepressants. But cardiac side effects after intoxication with the tetracyclic mianserin are rare. In this paper, we describe a case in which bradycardia and hypotension occured due to mianserin overdose. A 37-year-old woman was admitted to the medical intensive care unit for self-poisoning with 30 tablets of 10 mg mianserin 2 hours before her admission. The patient denied taking any other drugs. Four hours after her admission, bradycardia and hypotension occurred and she began to suffer from giddiness. Atropine and theophylline were given. On the second and third day, her heart rate and blood pressure were normal. Based on this case, we estimate the probability of bradycardia and hypotension in mianserin intoxication and the significance of closely monitoring the patient.
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Köseoğlu et al. (2010) conducted a case report in Mianserin intoxication (n=1). Mianserin overdose was evaluated on Bradycardia and hypotension. Mianserin overdose caused bradycardia and hypotension in a 37-year-old woman, which resolved after treatment with atropine and theophylline.
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