Why the study?
What are the intrarenal mechanisms contributing to the antihypertensive action of beta-adrenoceptor blocking drugs?
Design
Review
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Supports intrarenal mediation of beta-blocker effects; hypothesis-generating and requires prospective validation before changing practice.
What are the intrarenal mechanisms contributing to the antihypertensive action of beta-adrenoceptor blocking drugs?
Beta-blockers exert long-term antihypertensive effects largely through intrarenal mechanisms, including decreased renin release, enhanced tubular excretion, and shifts in the renal pressure-diuresis curve.
Struyker-Boudier et al. (1989) studied this question.
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