January 1, 2014Journal of Cardiovascular Magnetic ResonanceOpen Access

Comparison of canine ECV measurements derived from CMR: bolus injection vs. slow infusion of Gd-BOPTA

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Population

18 mongrel dogs with normal myocardium

Comparison

Bolus injection of Gd-BOPTA with CMR imaging 15… vs Slow infusion of Gd-BOPTA with CMR imaging 30…

Design

Preclinical

Authors

KHKyungpyo HongNorthwestern University EKEugene KholmovskiCardiac Imaging CMChristopher McGannCardiac Imaging

Discussion

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Implication

Strong canine correlation supports bolus ECV protocols in research; leaves open equilibrium assumptions and human validation.

Structured PICO

Population

18 mongrel dogs with normal myocardium

Intervention

Bolus injection of Gd-BOPTA (0.15 mmol/kg) with CMR imaging 15 min post-injection

Comparator

Slow infusion of Gd-BOPTA (0.002 mmol/kg/min) with CMR imaging 30 min post-infusion

Outcome

Agreement and correlation of myocardial extracellular volume (ECV) fraction measurements between the two protocolssurrogate

In canines, ECV measurements derived from bolus injection and slow infusion of Gd-BOPTA are strongly correlated but show slight differences, suggesting 15 minutes post-bolus may not represent dynamic equilibrium.

Cite This Study

Hong et al. (2014) studied this question.

synapsesocial.com/papers/6a91b07b05fd6a1e5860eef5 https://doi.org/10.1186/1532-429x-16-s1-p64

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Ask AI

Bookmark

Comparison of canine ECV measurements derived from CMR: bolus injection vs. slow infusion of Gd-BOPTA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparison of canine ECV measurements derived from CMR: bolus injection vs. slow infusion of Gd-BOPTA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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