February 1, 1994Proteins Structure Function and Bioinformatics

Crystallization and preliminary x‐ray diffraction studies of a monoclonal antibody fab fragment against foot‐and‐mouth disease virus and of its complex with the main antigenic site peptide

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Population

Fab fragment of the neutralizing monoclonal antibody SD6 elicited against foot-and-mouth disease virus…

Design

Preclinical

Authors

NVNúria VerdaguerInstitut de Biologia Molecular de Barcelona MMMauricio G. MateuCentro de Biología Molecular Severo Ochoa JBJerónimo BravoInstituto de Biomedicina de Valencia

Discussion

Member takes

Implication

Crystallization enables atomic modeling of FMDV antibody-peptide interactions; leaves open structure-guided therapeutic or vaccine development.

Structured PICO

Population

Fab fragment of the neutralizing monoclonal antibody SD6 elicited against foot-and-mouth disease virus (FMDV) C-S8c1 and its complex with a peptide corresponding to the major antigenic site of FMDV (VP1 residues 136-150, YTASARGDLAHLTTT)

Intervention

Crystallization using hanging drop vapor diffusion techniques

Outcome

Crystal diffraction resolution and unit cell parameterssurrogate

The study successfully crystallized the Fab fragment of a neutralizing antibody against FMDV and its complex with a viral peptide, enabling future structural analysis.

Cite This Study

Verdaguer et al. (1994) studied this question.

synapsesocial.com/papers/6a91b2bb4e5e0faf56534e5f https://doi.org/10.1002/prot.340180212

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Implication

Crystallization enables atomic modeling of FMDV antibody-peptide interactions; leaves open structure-guided therapeutic or vaccine development.

Crystallization and preliminary x‐ray diffraction studies of a monoclonal antibody fab fragment against foot‐and‐mouth disease virus and of its complex with the main antigenic site peptide

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Crystallization and preliminary x‐ray diffraction studies of a monoclonal antibody fab fragment against foot‐and‐mouth disease virus and of its complex with the main antigenic site peptide

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider