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May 27, 2022Frontiers in Aging NeuroscienceOpen Access

Participants with >66.7-100% of MVPA as VPA had a 30% lower risk for depression (OR = 0.70, 95% CI = 0.50, 0.99).

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Why the study?

Whether vigorous physical activity provides additional benefits for depression prevention compared with moderate physical activity remains unclear.

Does a higher proportion of vigorous physical activity to moderate-to-vigorous physical activity reduce the risk for depression in adults?

Population

12,939 adults performing any MVPA from NHANES 2007-2018

Comparison

Different proportions of VPA to MVPA

Design

Cross-sectional survey analysis

Authors

DYDonghui YangMYMing YangJBJianjun Bai

Discussion

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Overview

Higher VPA proportion within MVPA was associated with lower depression risk in men ≥45 years; leaves open prospective confirmation.

Structured PICO

Does a higher proportion of vigorous physical activity to moderate-to-vigorous physical activity reduce the risk for depression in adults?

P
Population
26,849 adults from the National Health and Nutrition Examination Survey (NHANES) 2007-2018, of which 12,939 performed any moderate-to-vigorous physical activity (MVPA).
I
Intervention
Higher proportion of vigorous physical activity (VPA) to moderate-to-vigorous physical activity (MVPA) (>66.7-100%)
C
Comparator
Lower proportion of VPA to MVPA
O
Outcome
Depression (defined as Patient Health Questionnaire-9 [PHQ-9] score ≥ 10)patient reported

A higher proportion of vigorous physical activity relative to total moderate-to-vigorous physical activity is associated with a lower risk of depression, particularly in men and adults aged 45 years and older.

Cite This Study

Yang et al. (2022) studied this question.

synapsesocial.com/papers/6a9228ce397d2e5be3b87ce0https://doi.org/10.3389/fnagi.2022.844414
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intensity, frequency, duration, and volume of physical activity and its association with risk of depression in middle- and older-aged Chinese: Evidence from the China Health and Retirement Longitudinal Study, 20152019 · 63 citations
  2. 2Dose-response relationship between accelerometer-measured physical activity and depression: evidence from the UK Biobank2025 · 10 citations
  3. 3The proportion of moderate-to-vigorous-intensity physical activity to total volume of physical activity is associated with cognitive and mental health in middle-aged and older adults2026
  4. 4Joint and dose‐dependent associations between aerobic and muscle‐strengthening activity with depression: A cross‐sectional study of 1.48 million adults between 2011 and 20172019 · 45 citations
  5. 5Association Between Physical Activity and Depression among Women: An Analysis of NHANES 2017–2018 Data2025