Population
isolated, blood-perfused canine atrial and ventricular preparations with heparinized arterial blood led from…
Design
Preclinical
Authors
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May warrant monitoring for bradycardia or reduced contractility with magnesium; leaves open translation from canine atria to human myocardium.
Magnesium chloride exerts direct, dose-dependent negative chronotropic and inotropic effects on the canine heart that are independent of muscarinic receptor activation.
Furukawa et al. (1981) studied this question.
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