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November 3, 2015Medical Science MonitorOpen Access

TNNT2 Gene Polymorphisms are Associated with Susceptibility to Idiopathic Dilated Cardiomyopathy in Kazak and Han Chinese

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Why the study?

Are TNNT2 gene polymorphisms associated with susceptibility to idiopathic dilated cardiomyopathy in Kazak and Han Chinese populations?

Population

360 individuals, comprising 180 patients with idiopathic dilated cardiomyopathy and 180 healthy controls…

Comparison

TNNT2 gene polymorphisms vs Healthy controls without IDCM

Design

Case-control

Authors

YLYaodong LiJiangsu UniversityYJYutong JiState Grid Corporation of China (China)XZXianhui ZhouXinjiang Medical University

Discussion

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Implication

May inform ethnic-specific risk assessment; leaves open prospective validation before clinical translation.

Structured PICO

Are TNNT2 gene polymorphisms associated with susceptibility to idiopathic dilated cardiomyopathy in Kazak and Han Chinese populations?

P
Population
360 individuals, comprising 180 patients with idiopathic dilated cardiomyopathy (IDCM) (90 Kazak and 90 Han) and 180 healthy controls (90 Kazak and 90 Han) from Xinjiang, China.
I
Intervention
TNNT2 gene polymorphisms (specifically SNP rs3729547)
C
Comparator
Healthy controls without IDCM
O
Outcome
Genotype distribution and allele frequency of TNNT2 gene polymorphismssurrogate

The TNNT2 gene polymorphism rs3729547 is associated with an increased susceptibility to idiopathic dilated cardiomyopathy in Kazak and Han Chinese populations.

Cite This Study

Li et al. (2015) studied this question.

synapsesocial.com/papers/6a9230b8b85aa34bb36c4512https://doi.org/10.12659/msm.894630
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1TBX5 loss-of-function mutation contributes to familial dilated cardiomyopathy2015 · 54 citations
  2. 2Contribution of Genetic Factors to the Pathogenesis of Dilated Cardiomyopathy - The Cause of Dilated Cardiomyopathy: Genetic or Acquired? (Genetic-Side) -2011 · 36 citations
  3. 3A DNA resequencing array for pathogenic mutation detection in hypertrophic cardiomyopathy2008 · 80 citations
  4. 4TNNT2Gene Polymorphisms Are Associated with Susceptibility to Idiopathic Dilated Cardiomyopathy in the Han Chinese Population2013 · 5 citations
  5. 5The Genetics of Dilated Cardiomyopathy: A Prioritized Candidate Gene Study of LMNA , TNNT2 , TCAP , and PLN2013 · 28 citations